16+ hour, 31+ min ago  (1753+ words) Schematic showing generation of destabilized supercoil F-actin by myosin forces, which is detected and stabilized through cooperative binding contacts by "-catenin. CTE, C-terminal extension. Grids were mounted on a Leica Cryo-CLEM microscope. Epifluorescence microscopy was performed using a 50" 0. 9 NA air…...

17+ hour, 26+ min ago  (1735+ words) Journal of Human Hypertension (2026)Cite this article The protein-protein interactions of 36 differentially expressed protein signatures were analyzed using the STRING database. The network was constructed with a confidence threshold of 0. 4, including direct and indirect interactions. The functional enrichments were derived…...

18+ hour, 53+ min ago  (1612+ words) Nature Protocols (2026)Cite this article DEq MS is a popular statistical tool for differential protein abundance analysis in quantitative mass spectrometry-based proteomics. The application and performance of the method are demonstrated using both "spike-in" and real-world datasets. This step-by-step Protocol…...

23+ hour, 29+ min ago  (218+ words) Focal adhesion kinase (FAK) is overexpressed and hyperactivated in triple-negative breast cancer, driving tumor aggressiveness and cancer stem cell'mediated therapy resistance. Therefore, targeting FAK signalling represents a promising therapeutic strategy. In this study, a series of indole and bis-indole-1, 2, 4-triazoles…...

1+ day, 5+ hour ago  (1078+ words) (a) Backbone RMSD of each A" fibril segment over 50 ns of REMD simulation in the presence of EPPS. Segments A and E showed early structural fluctuations, followed by delayed changes in other segments. (b) Per-residue RMSF of A" fibrils, highlighting increased flexibility…...

2+ day, 4+ hour ago  (1685+ words) Nature Cancer (2026)Cite this article In summary, we discovered that ferroptotic lipid peroxidation leads to an elevation in Golgi p H and identified that the Golgi-localized TMEM87 A acts as a ferroptosis suppressor by buffering Golgi p H. Loss of TMEM87 A can…...

3+ day, 4+ hour ago  (1719+ words) To identify kinases that are candidates for inhibition across cancers of multiple lineages, as well as kinases that are candidates for inhibition in cancers of specific lineages, we performed exploratory analyses using the Dep Map portal, which maps genetic dependencies…...

2+ day, 22+ hour ago  (1081+ words) The main text and supplementary information encompass all essential data, sequencing-related data have been upload to the SRA database (PRJNA1405099) and Mendeley Data, V1(doi: 10. 17632/dscmsyv6gn. 1). Additional data related to this research are accessible upon reasonable request from the first or corresponding author....

1+ week, 1+ day ago  (1683+ words) In the apo/inactivated state, Sp Xpr1 is auto-inhibited by a dual-gating mechanism involving the intracellular N-loop and extracellular ECLplug. The binding of endogenous activators, likely Ins P7 and Ins P8, allosterically relieves this inhibition by inducing rotation of the dimeric SPX domain,…...

5+ mon, 2+ week ago  (47+ words) The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogate publication patterns and to benchmark research performance. View the latest institution rankings…...