1+ hour, 45+ min ago   (549+ words) Using near-atomic cryo-EM, scientists mapped where pathogenic autoantibodies bind to NMDA receptors in the brain, identifying hotspots that could improve diagnosis and therapies for "Brain on Fire" disorder. The post Cryo-EM Maps Autoantibody Hotspots on NMDA Receptors in Autoimmune Encephalitis…...

20+ hour, 42+ min ago   (330+ words) Modulating the Secretory Pathway for Enhanced Therapeutic Protein Manufacturing'Genetic Engineering and Biotechnology News Avenue Biosciences received $5.7 million in seed extension to scale a high-throughput protein engineering technology designed to accelerate the discovery of protein-based tools and therapies. Balnord and Tesi…...

1+ day, 6+ hour ago   (530+ words) How Multiomics Data Shapes AI-Enabled Drug Discovery'Genetic Engineering and Biotechnology News Credit: Khanchit Khirisutchalual / iStock / Getty Images Plus Sponsored content brought to you by Those familiar with AI know it performs best when working with well-curated, human-generated data or documents,…...

3+ week, 2+ day ago   (251+ words) In a new study published in'Science Advances'titled, "Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD," researchers from'ETH Z'rich'have uncovered how histones H4 and H2A undergo the correct chemical modifications'during synthesis.'The findings offer new avenues for diseases of histone'dysregulation,'such…...

3+ week, 5+ day ago   (910+ words) New'vaccines that display'filovirus surface proteins on engineered, self-assembling protein nanoparticles'can improve immune system detection of the virus.'The nanoparticles triggered strong antibody responses across several filoviruses in mice, highlighting a promising path toward'viral protection.' The post Filovirus Detection by Immune…...

3+ week, 6+ day ago   (465+ words) The Dyadic Applied Solutions agreement will enable Fermbox Bio to manufacture and commercialize a growing portfolio of Dyadic-developed proteins and enzymes using both the Dapibus" and C1 expression systems. The post Animal-Free Protein and Enzyme Deal Expanded by Dyadic and Fermbox…...

4+ week, 2+ hour ago   (507+ words) The pathological features of Alzheimer's disease might once have been part of an orchestrated defense system against widespread infections in the brain when human lifespans were much shorter, scientists say. The post Brain's Viral Defense Mechanism Linked to Tau Pathology…...

4+ week, 2+ day ago   (594+ words) The lack of precise, tissue-by-tissue protein control in living organisms has been a bottleneck to understanding the mechanisms of aging. Researchers have now engineered the auxin-inducible degron (AID) system to tune protein levels in C. elegans. The post Plant Hormone Controls…...

1+ mon, 3+ day ago   (706+ words) Using the humble C. elegans as a model, scientists have identified mutations in mitochondrial genes that make up for the protein deficiency responsible for the rare neuromuscular disorder Friedreich's ataxia. The post Mutations in Mitochondrial Genes Ameliorate Pathology in Friedreich's Ataxia…...

1+ mon, 4+ day ago   (202+ words) By linking structural details, such as protein size and stability, with binding and interaction data, scientists should have the capability to make faster, more confident decisions earlier in development. The post Cytiva and Fida Biosystems Combine Technologies to Expand Protein…...