1+ day, 14+ hour ago  (297+ words) Neutron scattering, at the Institut Laue Langevin, shows how local density shapes motion within self-assembled protein structures image: Panoramic view inside IN16 B's secondary spectrometer at the Institut Laue Langevin (ILL). view more Neutrons are particularly well suited for studying proteins because…...

1+ day, 17+ hour ago  (222+ words) UNIGE scientists uncover a mechanism that regulates a central system for cellular balance, paving the way for new therapeutic strategies image: High-resolution cryo-EM models of TORC2 showing the flexible "cork" blocking the active site (1) or binding to membrane lipids (2). view more…...

2+ day, 14+ hour ago  (413+ words) In the study, the researchers analysed blood samples from 100 participants in the population-based BAMSE cohort at ages 4, 8, 16 and 24 years. Using advanced protein technology, over 5, 000 proteins were measured, of which just over 3, 500 could be tracked over time. More than half of…...

1+ day, 21+ hour ago  (290+ words) Researchers map early molecular and cellular changes in the jaw joint that may trigger temporomandibular joint osteoarthritis image: Schematic overview of the temporomandibular joint osteoarthritis (TMJ-OA) mouse models, showing the control, mechanical stress, and disc derangement groups, with multi-omics analyses…...

3+ day, 16+ hour ago  (737+ words) Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science Tokyo. They analyzed mouse embryonic forelimb cells across different developmental stages using single-cell-level…...

3+ day, 16+ hour ago  (621+ words) image: Anna "verby Wernstedt, Professor at the Department of Clinical Microbiology at Ume" University. view more Researchers at Ume" University have identified two human cell proteins, NUP98 and NUP153, that play a crucial role in how viruses such as tick-borne encephalitis virus…...

3+ day, 17+ hour ago  (472+ words) Same drivers of disease within microglia indicate that certain cancer treatments may be effective for Alzheimer's Microglia-like immune cells with cancer mutations (purple) emerge in the brain. Separately, clumps of proteins, like Tau or amyloid, accumulate in the brain, making…...

4+ day, 14+ hour ago  (180+ words) This diagram illustrates therapeutic strategies leveraging the chemokine system to modulate immune responses in cancer. The top panel highlights various cutting-edge approaches designed to enhance anti-tumor immunity by boosting the activity of chemokines and their receptors, thereby promoting the recruitment…...

4+ day, 13+ hour ago  (585+ words) image: University of Texas at Dallas biomedical engineering doctoral student Medel B. Lim Suan Jr. ; Dr. Faruck Morcos, associate professor of biological sciences; and Dr. P. C. Dave Dingal, assistant professor of bioengineering, built a machine-learning model that was able to suggest engineered…...

1+ mon, 1+ day ago  (640+ words) New study finds specialized insect produces bursts of heat and antifreeze proteins image: New research finds thesnow fly (Chionea alexandriana) counteracts subzero temperature by creating bursts of body heat and producing antifreeze proteins. view more Snow flies might be undergoing…...