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WebIBS and KAIST identify ERBB4 gene that breaks Alzheimer’s vicious cycle
14+ hour, 32+ min ago (756+ words) A Korean research team has identified a key regulatory gene that worsens Alzheimer’s disease, the main cause of dementia. There is growing expectation that by applying this newly discovered mechanism to develop novel therapies, it may become possible to fundamentally…...
NEDDylation Inhibitor Identified as Dual-Action Target for Osteoporosis at Seoul National University
6+ day, 30+ min ago (287+ words) Study in Experimental & Molecular Medicine shows NAE1–NEDD8 pathway controls both bone resorption and formation after menopause Seoul National University announced on the 21st that the research team led by Professor Yang-Sook Chun at the College of Medicine has identified a new molecular…...
UNIST identifies TET protein strategy that boosts cellular mitochondria to combat obesity
3+ week, 3+ day ago (334+ words) TET controls Parkin to increase mitochondrial heat production in beige adipose tissue under cold exposure The principle by which fat cells in the body enhance the heat-producing capacity of mitochondria, the “stoves inside cells,” has been identified. The finding is…...
AI model Raygun reshapes protein size while preserving function
3+ week, 6+ day ago (401+ words) Duke University uses LLM-based design to expand and shrink proteins for cancer targets and biosensors Using artificial intelligence (AI), researchers have developed a technology that can shrink or enlarge proteins while maintaining their structure and function. It is being hailed…...
KAIST blood test maps amino acid networks to predict colorectal cancer relapse and metastasis
1+ mon, 5+ day ago (261+ words) A single blood test may soon allow doctors to predict the risk of relapse and metastasis in colorectal cancer patients more accurately than current methods. By harnessing changes in this metabolic connectivity, the team developed a new analytical technique that…...
KOPRI team identifies muscle regeneration switch protein in Antarctic fish
1+ mon, 6+ day ago (345+ words) Discovery of Dnajb5’s dual brake mechanism suggests new therapies for sarcopenia and cachexia A protein that regulates muscle regeneration and growth has been discovered in an Antarctic fish. A Korean research team has, for the first time in the world,…...
Google DeepMind’s AlphaFold3 predicts dynamic protein structures with ISTA
1+ mon, 3+ week ago (267+ words) Google DeepMind’s artificial intelligence (AI) tool AlphaFold, which predicts three-dimensional protein structures, has now evolved to the point where it can forecast the dynamic motions of proteins. It can predict multiple structures that proteins may adopt in real biological environments....
King’s College London identifies karyoptosis driving neuronal loss in dementia
2+ mon, 1+ day ago (344+ words) Shrinking nuclei in Alzheimer’s and frontotemporal dementia reveal a new cell death pathway and potential drug targets Researchers have uncovered a clue that may explain the loss of neurons in patients with neurodegenerative diseases, which has been difficult to account…...
Seoul National University team develops Folddisco to search AI-predicted protein structures 20 times faster
2+ mon, 2+ week ago (360+ words) New software indexes structural motifs in hundreds of millions of AlphaFold2 protein models while using just one quarter of the storage The National Research Foundation of Korea (NRF) announced on the 11th that a team led by Professor Martin Steinegger at Seoul…...
MRC Laboratory of Molecular Biology identifies ADX pathway for infected cells to destroy pathogens
2+ mon, 3+ week ago (369+ words) When pathogens invade the body, immune cells such as white blood cells launch an attack. Scientists have now discovered another major pathway by which our body fights pathogens. They have confirmed that cells infected by pathogens themselves act as immune…...