9+ mon, 3+ day ago  (428+ words) The development of fluorescent probes for imaging in Alzheimer's disease has rapidly expanded, with these molecular tools enabling the non-invasive visualisation of pathological biomarkers such as. .. Fluorescent Probes for Imaging in Alzheimer's Disease The development of fluorescent probes for imaging…...

9+ mon, 3+ day ago  (317+ words) Beta'propeller protein'associated neurodegeneration (BPAN) is a rare, X'linked neurodegenerative disorder that forms part of the broader spectrum of neurodegeneration with brain iron accumulation. .. Beta'propeller protein'associated neurodegeneration (BPAN) is a rare, X'linked neurodegenerative disorder that forms part of the broader spectrum…...

9+ mon, 3+ day ago  (433+ words) Hereditary spastic paraplegia (HSP) comprises a heterogeneous group of neurodegenerative disorders that are mainly characterised by progressive spasticity and weakness of the lower limbs. Recent. .. Hereditary Spastic Paraplegia and KIF1 A Mutations Hereditary spastic paraplegia (HSP) comprises a heterogeneous group of…...

9+ mon, 3+ day ago  (426+ words) Alpha-1 antitrypsin deficiency (AATD) is a hereditary condition characterised by the misfolding of the alpha-1 antitrypsin (AAT) protein, resulting in its hepatic accumulation and compromised protease. .. Alpha-1 Antitrypsin Deficiency And Related Disorders Alpha-1 antitrypsin deficiency (AATD) is a hereditary condition…...

10+ mon, 1+ week ago  (47+ words) The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogate publication patterns and to benchmark research performance. View the latest institution rankings…...

9+ mon, 3+ day ago  (392+ words) Pichia pastoris has emerged as a central microbial host for recombinant protein production, offering a unique balance of rapid growth, capacity for post'translational modifications, and ease of. .. Pichia Pastoris in Recombinant Protein Production Pichia pastoris has emerged as a central…...

3+ day, 23+ hour ago  (1730+ words) We also generated focused libraries of "-lactamase chimeras with circular permutated minibinders of the Vir B8-like and MDM2 proteins15 (Fig. 2g and Supplementary Fig. 4e, f). In both cases, we were able to obtain chimeras with ligand-controlled enzymatic activity (Fig. 1g and Supplementary Fig. 4g). These results…...

4+ day, 8+ hour ago  (360+ words) Medications based on glucagon-like peptide 1 pathways are an efficient drug treatment for people with obesity, often eliciting rapid and pronounced weight loss. However, concerns have been raised regarding accelerated muscle wasting and sarcopenia. Here, we discuss some of the latest…...

9+ mon, 3+ day ago  (481+ words) Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to the regulation of numerous cellular processes, including stress response, inflammation, cell cycle control and apoptosis. Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to…...

3+ mon, 1+ week ago  (92+ words) A few studies have suggested that after binding a kinase, some inhibitors induce kinase destabilization, resulting in inhibitor-induced target degradation. However, the mechanisms underlying this phenomenon are not well-understood. Nature Reviews Drug Discovery 25, 97 (2026) Shanghai, Beijing, or Pune, Hybrid Working Model…...