7+ hour, 21+ min ago  (684+ words) LFQ relies on measuring peptide signal intensity directly from the mass spectrometer without the use of chemical or metabolic labels. Each sample is prepared and analyzed in an independent LC'MS/MS run, and quantitative comparison occurs during computational analysis rather…...

4+ day, 23+ hour ago  (252+ words) Laura holds a BSc in Zoology from Queen Mary University of London, an MSc in Palaeoanthropology from UCL, and a PhD in Environmental Sciences from Royal Holloway, University of London. Her academic journey has been fueled by a broad interest…...

5+ day, 23+ hour ago  (113+ words) The choice of software often depends on the specific requirements of the experimental design, the available computational resources, and the desired depth of analysis. Table 1. Comparative analysis of leading proteomics software platforms Sequest HT / Mascot Modern platforms are increasingly optimized…...

5+ day, 23+ hour ago  (512+ words) In large-scale proteomics, the volume of data generated makes manual validation of every spectrum impossible. Consequently, the field has adopted the target-decoy approach to estimate and control the false discovery rate (FDR) (Table 1). This involves searching the MS/MS spectra…...

1+ week, 3+ day ago  (556+ words) Drug discovery pipelines are notorious for being costly, slow, and failure-prone, leading to AI and machine learning becoming more commonplace to accelerate progress and improve outcomes. Currently, machine learning in drug discovery centers around data-rich stages, which provide plentiful data…...

1+ mon, 1+ week ago  (327+ words) A major advance in cell biology has revealed how our cells safeguard their genetic material during one of the most vulnerable moments in their life cycle. The study identifies a specific protein complex as a central coordinator of DNA repair…...

1+ mon, 1+ week ago  (242+ words) Membrane proteins are some of the most valuable targets in drug discovery, accounting for over half of all therapeutic targets. However, their inherent structural diversity and the complexity of their preparation often make them difficult to work with in screening…...

1+ mon, 1+ week ago  (142+ words) How Brain Cells Break Down Toxic Proteins May Contribute to Alzheimer's Development'Technology Networks Researchers at the Technion Faculty of Biology have discovered that a mechanism responsible for breaking down toxic proteins, and known to be involved in the development of…...

1+ mon, 1+ week ago  (466+ words) The immune system provides constant surveillance for the body, aiming to spot and eliminate disease-causing microbes or cancerous cells. But tumour cells develop many features that help them hide from the immune system to avoid being detected and killed." "It's…...

1+ mon, 2+ week ago  (367+ words) To overcome this, Han and his colleagues at CardiaTec are generating high-quality, unbiased multiomic data to build the largest multiomics database of human cardiac tissue. "What we have set out to do is generate multiomics data from the same tissue…...