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Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection - Nature Protocols
5+ hour, 52+ min ago (1653+ words) Nature Protocols (2026)Cite this article This Protocol Extension describes the delivery of Pseudomonas aeruginosa and other bacteria into the adult Drosophila intestine by feeding. The unique feature of this protocol is that intestinal infection is physiologically distinct from the previously…...
Bridging technical innovation and computational advances in studies of RNA–protein assemblies - Nature Reviews Genetics
10+ hour, 28+ min ago (1784+ words) Nature Reviews Genetics (2026)Cite this article Hentze, M. W., Castello, A., Schwarzl, T. & Preiss, T. A brave new world of RNA-binding proteins. Nat. Rev. Mol. Cell Biol. 19, 327341 (2018). Gebauer, F., Schwarzl, T., Valc'rcel, J. & Hentze, M. W. RNA-binding proteins in human genetic disease. Nat. Rev. Genet. 22, 185198 (2021). Buccitelli, C. & Selbach, M. mRNAs, proteins and…...
Vacuolar myopathy caused by CASQ1 p.Asp244His: pathogenic evidence from two unrelated Chinese families - Journal of Human Genetics
18+ hour, 17+ min ago (644+ words) Journal of Human Genetics (2026)Cite this article MacLennan DH, Wong PT. Isolation of a calcium-sequestering protein from sarcoplasmic reticulum. Proc Natl Acad Sci USA. 1971;68:12315. Damiani E, Volpe P, Margreth A. Coexpression of two isoforms of calsequestrin in rabbit slow-twitch muscle. J…...
Metadynamics reveals luteolin-mediated conformational stabilization against avapritinib-resistant PDGFRα D842V/G680R GIST - Scientific Reports
18+ hour, 17+ min ago (129+ words) 2D Interaction diagrams of the complexes PDGFR" D842V/G680R with avapritinib (+Luteolin) (left) and PDGFR" D842V/G680R with avapritinib (right) over MD Simulation at 300ns. Schr'dinger Release 2020-1: Desmond Molecular Dynamics System, Shaw, D. E. & Research New York, NY, 2020. (Maestro-Desmond Interoperability Tools, Schr'dinger, New York, NY, 2020). Medical Biotechnology Laboratory…...
BRD4 orchestrates the metabolic-epigenetic regulation of GM-CSF expression and secretion to drive PD-L1⁺ macrophage-mediated immune evasion in triple-negative breast cancer - Oncogene
2+ day, 14+ hour ago (1852+ words) Oncogene (2026)Cite this article Receive 50 print issues and online access only $5.18 per issue The data that support the findings of this study are available from the corresponding author upon reasonable request. Ligorio F, Vingiani A, Torelli T, Sposetti C, Drufuca…...
The TP53 gene contains a diversity box that makes it more than a tumor suppressor - Cell Death & Differentiation
3+ day, 9+ hour ago (592+ words) Cell Death & Differentiation (2026)Cite this article The TP53 gene is a tumor suppressor gene. This gene can express 12 splice variants and isoform proteins. The protein can form monomers, dimers and tetramers. The human TP53 gene has 14 polymorphisms with known phenotypes. There are…...
Ectosomes step forward in α-synuclein spread - Nature Cell Biology
3+ day, 10+ hour ago (296+ words) We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics…...
Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model - Experimental & Molecular Medicine
3+ day, 14+ hour ago (1550+ words) The abnormal accumulation of hyperphosphorylated tau in neurofibrillary tangles is a hallmark of neurodegenerative diseases, such as Alzheimer's disease (AD) and frontotemporal dementia. In AD, tangle pathology characteristically develops in brain regions with heightened vulnerability, such as the entorhinal cortex…...
Defining the reference proteomes for small extracellular vesicles and non-vesicular components - Nature Cell Biology
3+ day, 18+ hour ago (1690+ words) Nature Cell Biology (2026)Cite this article Only proteins classified as sEV in at least 14 out of the 15 cell lines used in this study were used for the co-expression analysis (ARF6 which was classified as sEVs in 12 cell lines was included). Spearman…...
Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction - Communications Biology
3+ day, 18+ hour ago (1705+ words) The datasets analyzed during the current study are available as Supplementary Data1 in Excel format. All uncropped and unedited blots are included as Supplementary Figs.915. Any other information related to this manuscript is available from the corresponding author on reasonable request....