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Tumor PD-L1 induces β2m ubiquitylation and degradation for cancer cell immune evasion
5+ hour, 8+ min ago (1108+ words) Cell Research (2026)Cite this article Receive 12 digital issues and online access to articles only $9.92 per issue Zou, W., Wolchok, J. D. & Chen, L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci. Transl. Med. 8, 328rv324 (2016). Vesely, M. D., Zhang, T. & Chen, L. Resistance Mechanisms…...
The gene-regulating proteins NONO and SFPQ assemble into ordered filaments
1+ day, 22+ hour ago (1310+ words) Knott, G. J., Bond, C. S. & Fox, A. H. The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold. Nucleic Acids Res 44, 39894004 (2016). Yu, D., Huang, C.-J. & Tucker, H. O. Established and evolving roles of the multifunctional non-POU domain-containing octamer-binding protein (NonO) and splicing factor proline- and glutamine-rich (SFPQ). J. Dev. Biol....
Assessing the potential of deep learning for protein–ligand docking
2+ day, 1+ hour ago (1406+ words) A preprint version of the article is available at arXiv. Our benchmark results also highlight the importance of including challenging (out-of-distribution) datasets when evaluating future DL methods and measuring their ability to recapitulate amino acid-specific PLIFs with an appropriate new…...
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
3+ day, 1+ hour ago (1571+ words) Historical overview of mTOR research and its clinical application. The timeline illustrates key discoveries in the mTOR signaling pathway (upper panel) and parallel progress in the identification and clinical application of mTOR-targeting agents (lower panel). See the text for details…...
Computational screening and molecular modeling of probiotic-derived peptides targeting the conserved HR1 domain of SARS-CoV-2 spike protein
3+ day, 12+ hour ago (1747+ words) Structural integrity: Only peptides with complete backbone atoms and side chains were retained. Length limitation: Peptides exceeding 60 amino acids were omitted due to reduced druggability and increased computational complexity. Resolution threshold: For PDB-sourced structures, only those with a resolution of…...
Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease
3+ day, 13+ hour ago (1682+ words) Design and characteristic evaluation of backing.(a) Schematic design of the MAP and its 3D-printed backing layer. Cross-sectional schematics showing pillar position and microneedle tip-filling. (b) Optical microscopic images of the fabricated backing pillars. From the theoretical calculation method, the PG method…...
The downregulation of RIZ1 activates the AKT/mTOR in pregnant women with obesity
3+ day, 14+ hour ago (1499+ words) In this study, we enrolled pregnant women with different BMIs in the early stages of pregnancy, investigated their diets, and further detected whether the high BMI pregnant women with decreased RIZ1 and activated AKT/mTOR in white blood cells. Activation of…...
SHP2 in tumor-associated macrophages prompted the progression of colorectal cancer via modulating STAT3/PI3K signaling induced PD-1-mediated CAR-T cell apoptosis
3+ day, 15+ hour ago (866+ words) The GSE28000 colorectal cancer dataset was selected from the GEO database and was subjected to differential gene analysis by the DEseq2 package and visualised by the ggplot2 package to draw volcano plots (log2FC>1 p Given the above, activation of TAM-intrinsic SHP2 is significantly associated with…...
PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
3+ day, 16+ hour ago (1844+ words) Oncogene (2025)Cite this article Receive 50 print issues and online access only $5.18 per issue All data that support the findings of this study are available from the corresponding authors upon reasonable request, without any restrictions. Bray F, Laversanne M, Sung H,…...
Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex
3+ day, 19+ hour ago (1704+ words) RNA-sequencing data and analysis results are available in Supplementary Tables 14. Source data are provided with this paper. Stoeckli, E. T. Understanding axon guidance: are we nearly there yet? Development 145, dev151415 (2018). Maday, S., Twelvetrees, A. E., Moughamian, A. J. & Holzbaur, E. L. F. Axonal transport: cargo-specific mechanisms of motility and regulation. Neuron…...