7+ hour, 44+ min ago   (430+ words) The way cancer-causing proteins accumulate in tumors may influence how effectively a promising new generation of medicines can remove them, a study suggests. Researchers found that PROTAC (Proteolysis Targeting Chimeras) drugs were more effective at removing proteins that build up…...

7+ hour, 53+ min ago   (445+ words) Our ideas about what's important in biology are often defined by the tools that we have to look at it. There's a lot of biology happening inside a black box that we can't see. If we can amplify signals that…...

4+ day, 13+ hour ago   (106+ words) LMU researchers identify a molecular mechanism that enables single-celled parasites to switch on the machinery they need to move and invade host cells. What surprised us is that methylation is not acting here in the nucleus, where it is best…...

6+ day, 10+ hour ago   (107+ words) Importantly, more than half of patients with BRCA1/2 mutations remained on niraparib treatment for at least three years, highlighting the feasibility of long-term maintenance therapy in routine clinical practice. Exploratory analyses identified several factors associated with prolonged PFS, including postoperative R0 resection,…...

1+ week, 4+ day ago   (381+ words) A comprehensive review published in Engineering systematically outlines the regulatory capacity of silent information regulator 3 (SIRT3), a mitochondrial deacetylase termed the "head goose molecule", and its negentropic mechanism for intervening global metabolic disorders including type 2 diabetes, obesity, and steatotic liver disease....

1+ week, 5+ day ago   (705+ words) Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a study by Weill Cornell Medicine investigators. The preclinical study, published Aug. 20 in Nature Metabolism,…...

1+ week, 6+ day ago   (294+ words) With more accuracy and less time, a new deep-learning method called PRIME makes the search for metal-binding sites easier. Now, researchers from Hokkaido University have developed a new, fast, and accurate way to predict these metal-binding sites. Their method, called…...

2+ week, 5+ day ago   (183+ words) The researchers found that soybean oil increased OPA1 expression in male wild-type mice but not in females. The mice lacking OPA1 showed increased food intake, age-related weight gain, and the development of obesity. When given free access to both standard chow and…...

2+ week, 6+ day ago   (213+ words) Wiley, a global leader in authoritative content and research intelligence, today released the new edition of the Wiley Registry/NIST Mass Spectral Library, a reference database that combines two essential mass spectrometry references in a single, integrated collection, giving scientists…...

3+ week, 1+ day ago   (278+ words) Spinal cord injury begins with immediate mechanical damage, but much of the lasting neurological loss develops during the secondary phase, when inflammation, oxidative stress and disrupted metabolism continue to injure surviving tissue. Newly discovered protein pathway limits spinal cord injury…...