News
Artificial allosteric protein switches with machine-learning-designed receptors - Nature Biotechnology
2+ day, 1+ hour ago (1730+ words) We also generated focused libraries of "-lactamase chimeras with circular permutated minibinders of the Vir B8-like and MDM2 proteins15 (Fig. 2g and Supplementary Fig. 4e, f). In both cases, we were able to obtain chimeras with ligand-controlled enzymatic activity (Fig. 1g and Supplementary Fig. 4g). These results…...
Causes of sarcopenia and frailty in people taking GLP1 RAs - Nature Reviews Endocrinology
2+ day, 10+ hour ago (360+ words) Medications based on glucagon-like peptide 1 pathways are an efficient drug treatment for people with obesity, often eliciting rapid and pronounced weight loss. However, concerns have been raised regarding accelerated muscle wasting and sarcopenia. Here, we discuss some of the latest…...
Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors
9+ mon, 1+ day ago (481+ words) Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to the regulation of numerous cellular processes, including stress response, inflammation, cell cycle control and apoptosis. Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to…...
Kinase inhibitors trigger target degradation
3+ mon, 5+ day ago (92+ words) A few studies have suggested that after binding a kinase, some inhibitors induce kinase destabilization, resulting in inhibitor-induced target degradation. However, the mechanisms underlying this phenomenon are not well-understood. Nature Reviews Drug Discovery 25, 97 (2026) Shanghai, Beijing, or Pune, Hybrid Working Model…...
Congenital Disorders of Glycosylation
9+ mon, 1+ day ago (499+ words) (CDGs) comprise a heterogeneous group of inherited metabolic conditions resulting from defects in the glycosylation machinery. These disorders disrupt the normal. .. Congenital Disorders of Glycosylation Congenital Disorders of Glycosylation (CDGs) comprise a heterogeneous group of inherited metabolic conditions resulting from…...
Amyloidosis and Cardiac Health
9+ mon, 1+ day ago (407+ words) Amyloidosis represents a heterogeneous group of disorders defined by the extracellular deposition of misfolded protein fibrils, which can cause severe impairment in multiple organs. In the context of. .. Amyloidosis and Cardiac Health Amyloidosis represents a heterogeneous group of disorders defined…...
Amyloid Fibril Formation and Protein Aggregation in Alzheimer's Disease
9+ mon, 1+ day ago (432+ words) The formation of amyloid fibrils and the aggregation of misfolded proteins are central to the pathology of Alzheimer's disease. At the molecular level, normal proteins adopt aberrant conformations. .. Amyloid Fibril Formation and Protein Aggregation in Alzheimer's Disease The formation of…...
Why some cancer-fighting immune cells lose their strength inside tumours
2+ week, 1+ day ago (239+ words) Scientists have identified a reason why certain crucial immune cells lose their vigour inside a tumour: their mitochondria become debilitated, according to a study1 in mice. You, Z. et al. Science 392, eadv6582 (2026). Krawczyk, C. M. et al. Blood 115, 47424749 (2010). Why obesity drugs work better for some…...
Design of intrinsically disordered region binding proteins
9+ mon, 17+ hour ago (89+ words) The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogate publication patterns and to benchmark research performance. China's lead in the Nature…...
Protein Folding and Knotting Dynamics
9+ mon, 1+ day ago (471+ words) Protein folding is a critical process by which linear chains of amino acids adopt specific three'dimensional conformations essential for biological function. In recent years, studies have increasingly. .. Protein Folding and Knotting Dynamics Protein folding is a critical process by which…...