5+ hour, 43+ min ago   (539+ words) Scientists working their way back through millions of years of the evolutionary past of mammalian lactoferrin reconstructed extinct peptides, some of which in laboratory were more potent against drug-resistant bacteria than present-day counterparts. The post Ancient Peptides Resurrected from Lactoferrin’s…...

7+ hour, 41+ min ago   (179+ words) Bats are among the most diverse mammalian species—second only to rodents—and are anomalies in the mammalian world: they fly, have long lifespans for their size, and rarely get cancer. Scientists now provide insights into these unique characteristics in…...

9+ hour, 20+ min ago   (380+ words) By Gareth John Macdonald Endonuclease enzymes play a vital role in modern biopharmaceutical production, yet manufacturing them in bulk using traditional E. coli systems is challenging. New research suggests secretory expression could be a more effective alternative. In biopharmaceutical manufacturing, endonucleases…...

5+ day, 10+ hour ago   (297+ words) Rather than generating new wet-lab data for every compound, DeepCyte trains a foundation model that is capable of predicting toxicity mechanisms for compounds that it has never measured. The post DeepCyte Launches Single-Cell Metabolomic Reference Atlas of Drug Toxicity Mechanisms…...

6+ day, 7+ hour ago   (257+ words) Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) say they have created the first systematic catalog of the substrate receptors of cullin–RING ligases and analyzed how their genetic variants may translate into disease symptoms....

1+ week, 5+ day ago   (452+ words) Our cells need iron to produce energy, carry oxygen throughout the body and power countless chemical reactions that sustain life. But when too much iron is left free inside cells it can trigger destructive reactions that break down DNA, proteins,…...

2+ week, 5+ day ago   (201+ words) Protein degraders remove unwanted proteins from inside a cell by disposing of them using the cell’s built-in recycling system. Specifically, a molecular glue degrader binds an E3 ligase and redirects it to tag a disease-related protein for disposal. The study was…...

2+ week, 5+ day ago   (212+ words) The Gates Foundation awarded a $500,000 Grand Challenges grant to a University of Connecticut (UConn) researcher specializing in the development and commercialization of sustainable food products using algae and other natural materials. Many view Qiao as an innovator in the eco-manufacturing…...

3+ week, 5+ day ago   (441+ words) Through a multistep process, signals from infected cells trigger the formation of a receptor complex that directs neutrophils out of blood vessels toward infection sites without damaging healthy tissue. The post Molecular GPS Guides Neutrophils to Sites of Infection appeared…...

3+ week, 6+ day ago   (453+ words) Researchers at Washington University School of Medicine in St. Louis and at Syracuse University have now built a tool that can design such “disordered” proteins (intrinsically disordered protein regions; IDRs) and untangle their functionality. The team suggests the innovation has…...