News
AI & Antibodies mini-series | An artificial approach to humanization
2+ hour, 52+ min ago (1015+ words) Antibody humanization presents a major challenge in antibody therapeutic development, but how could AI help resolve it?...
Secret world of cellular communication visualized in 3 D thanks to new nanoscopy method
1+ week, 5+ day ago (21+ words) A new nanoscopy technique has uncovered hidden networks used for cell-to-cell communication, opening new ways to understand human diseases....
Dual-ligase strategy adds new layer of control to targeted protein degradation
3+ week, 2+ hour ago (367+ words) Original story from the Ce MM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna, Austria). The mechanism by which a small molecule can use two distinct pathways for degrading its target protein has been identified, offering…...
A light at the end of the tunnel for Huntington's disease treatment
3+ week, 4+ day ago (20+ words) New research reveals how tunneling nanotubes allow proteins to spread between cells, offering a promising target for Huntington's disease....
New genetic discovery could spell this aggressive cancer's downfall
1+ mon, 1+ day ago (20+ words) Identifying a vulnerability of small cell neuroendocrine cancer could lead to a treatment strategy for these difficult-to-treat tumors....
Accelerating antibody development with a novel platform
8+ mon, 3+ week ago (301+ words) Original story from the University of Illinois Urbana'Champaign (IL, USA). The o Pool+ display platform combines technologies to make and test large numbers of antibodies at once. Dubbed the o Pool+ display, the method they developed could drastically accelerate antibody…...
Illuminating the link between amyloid beta and tau in Alzheimer's disease
2+ mon, 1+ week ago (291+ words) Original story from the University of California Riverside (CA, USA)." New research suggests Alzheimer's arises not simply from plaques forming in the brain, but from one protein interfering with the normal job of another. "In addition to having dementia, Alzheimer's…...
Cancer drug could reverse hyperconnectivity in early Alzheimer's
2+ mon, 3+ week ago (666+ words) Original story from King's College London (UK). Neuroscientists at King's College London (UK) have pinpointed a mechanism behind the increased neural connectivity seen in very early stages of Alzheimer's disease. Published in Translational Psychiatry, the study then demonstrated that a…...
How to make cancer therapies BETter: an insight into the distinct roles of BET proteins
1+ mon, 3+ week ago (145+ words) Original story from the Max Planck Institute of Immunobiology and Epigenetics (Freiburg, Germany). Understanding the distinct roles of BET proteins could unlock a more targeted approach to cancer therapy. A new study from the Max Planck Institute of Immunobiology and…...
Shining a blue light on an overlooked posttranslational modification
1+ mon, 3+ week ago (257+ words) Original story from Rice University (TX, USA). A simple way to study a common but overlooked posttranslational modification has been developed, unlocking new insights into how proteins function Pyroglutamate occurs when a chemical reaction makes a ring at an amino…...