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News
AI BioDesign Initiative Aims To Design Proteins Nature Never Produced
1+ week, 2+ day ago (457+ words) Evolution has created an astonishing amount of diversity, shaping much of our understanding of biology. But this diversity, which took billions of years to emerge, barely scratches the surface of what could have existed given the trillions of possible DNA…...
Imaging Reveals How a Tumor-Fighting Drug Triggers Cellular Breakdown
1+ week, 3+ day ago (343+ words) Technology Networks Cancer drugs are often designed to block specific molecular targets, but what happens after they enter a cell is not always well understood Using super-resolution microscopy, researchers tracked the cancer drug sunitinib inside living cells and observed how…...
Whole-Body Proteome Atlas Reveals 41 Potential Cancer Drug Targets
2+ week, 5+ day ago (575+ words) If the human genome is a static blueprint of life, the human proteome acts as a real-time GPS, tracking how cells move, mature, and malfunction. Scientists at Westlake University built a whole-body navigation system by mapping protein distributions across healthy,…...
AI Predicts Metal-Binding Sites in Proteins With High Speed and Accuracy
3+ week, 2+ day ago (250+ words) Now, researchers from Hokkaido University have developed a new, fast, and accurate way to predict these metal-binding sites. Their method, called PRIME (Probe-based Identification of Metal-binding sites), is described in Nature Communications and uses a deep-learning approach to solve this…...
Ancient Mitochondrial Program Monitors Cellular Heme Concentrations
1+ mon, 5+ day ago (39+ words) Technology Networks An ancient mitochondrial program tunes translation to haem availability doi: 10.1038/s41586-026-10885-xThis article has been republished from the following materials Note: material may have been edited for length and content...
Raygun Generates Shorter and Longer Functional Protein Variants
1+ mon, 6+ day ago (250+ words) Researchers at Duke University School of Medicine have developed an artificial intelligence framework that can redesign proteins on a scale previously seen only in natural evolution. The tool can create shorter, longer, and highly modified versions of proteins while preserving…...
Deleting Immune Cell Signaling Molecule Enhances Muscle Regeneration
1+ mon, 1+ week ago (10+ words) Technology Networks...
Parkinson's-Linked VPS13 Protein Found in Distinct Functional States
1+ mon, 1+ week ago (639+ words) Researchers at Yale School of Medicine have conducted the first comprehensive structural analyses of a class of proteins whose dysfunction is associated with neurodegenerative diseases. In two new studies published in Cell and Molecular Cell, researchers investigated, at the atomic…...
Ancient Proteomics Reveals How Brains Survive for Millennia
1+ mon, 1+ week ago (859+ words) Long after the rest of a buried body has turned to dust, why does brain tissue sometimes refuse to decay? In a new study, researchers tracked over 1.2 million peptide trajectories to map out this preservation pathway. The results revealed that…...
Scientists Build Platform To Explore Disordered Protein Biology
1+ mon, 1+ week ago (470+ words) Now, researchers from Washington University School of Medicine in St. Louis and Syracuse University have built a tool that can design such “disordered” proteins and untangle their functionality. The innovation has the potential to accelerate the scientific exploration of a…...