News
Remembering inflammation increases cancer risk | Nature Reviews Cancer
22+ hour, 13+ min ago (117+ words) Nature Reviews Cancer (2026) Cite this article Colitis is a chronic inflammatory disease and an established risk factor for developing colorectal cancer, yet the role of inflammation in tumour initiation was previously unclear. Nagaraja et al. now show in mice that…...
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis - Nature Aging
22+ hour, 13+ min ago (1545+ words) Nature Aging (2026) Cite this article All source data will be provided as a Source Data file. Other data will be available from the corresponding author upon reasonable request. Martinez, B. P. et al. Frequency of sarcopenia and associated factors among hospitalized elderly…...
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology | Nature Aging
22+ hour, 13+ min ago (1731+ words) Nature Aging (2026) Cite this article HIP, EC and PFC tissues from WT, 5x FAD, 5x FAD; Ulk1 OV and Ulk1 OV mice were processed for transmission electron microscopy with minor modifications to established protocols76, 101. Tissues were cut into small pieces ( RNA-seq data are available at…...
Engineering proteins with Sequence Display | Nature Methods
1+ day, 22+ hour ago (136+ words) Engineering proteins with Sequence Display Nature Thank you for visiting nature. com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn…...
Large-scale discovery, analysis and design of protein energy landscapes
1+ day, 22+ hour ago (1700+ words) Nature (2026) Cite this article In both cases, global models were trained on the full dataset and evaluated on individual PFs, while family-specific models were developed for PFs with more than 200 examples. Model performance was assessed using the R2 score aggregated across…...
Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells - Cell Death & Disease
2+ day, 22+ hour ago (134+ words) Cell Death & Disease (2026) Cite this article CNR Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza, Unit of Bologna, Bologna, Italy Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genova, Italy Child Neurology and Psychiatry Unit, IRCCS Istituto delle Scienze…...
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation - Nature Chemical Biology
2+ day, 22+ hour ago (1709+ words) Nature Chemical Biology (2026) Cite this article In sum, these findings demonstrate that, in addition to chemical tuning, ligase choice can be genetically fine-tuned through specific substitutions at the degrader'ligase interface. In particular, the L59 W substitution enhances DCAF16 engagement by 2 and 3, likely…...
About the Guest Editors | Precision nutrition for animal health and performance
5+ day, 18+ hour ago (109+ words) This Collection supports and amplifies research related to'SDG 2,'SDG 3,'SDG 13. Research has shown that precision feeding strategies can significantly reduce crude protein intake by up to 25%, while lowering nitrogen excretion into the environment by as much as 40%. At the same…...
Undruggable" cancer proteins meet their match
6+ day, 22+ hour ago (46+ words) People with a deadly form of pancreatic cancer survive longer on a drug that blocks the activity of a family of mutant proteins. People with a deadly form of pancreatic cancer survive longer on a drug that blocks the activity…...
The latest AI breakthroughs in structural biology: protein binder design and conformational state prediction - Communications Biology
6+ day, 22+ hour ago (907+ words) This Comment presents the idea that today we are standing at the doorsteps of new breakthroughs that will probably make less noise than the original "Alpha Fold 2 moment" yet will be as or even more impactful. We are approaching a…...