3+ day, 6+ hour ago   (318+ words) An analysis of nearly 1000 prostate tumor samples has revealed eight integrated mutational footprints (IMFs) that underpin the majority of genetic alterations found in prostate cancer genomes, some of which reflect clinical outcomes. Although prostate cancer has a high prevalence, the…...

3+ day, 10+ hour ago   (474+ words) A comprehensive genomic profiling study involving more than 13,000 patients has shown that targetable G12C mutations in the KRAS oncogene are rare in genitourinary cancers, potentially limiting the role of routine testing and targeted treatment in these malignancies. KRAS G12C accounts for approximately…...

1+ week, 3+ day ago   (763+ words) The genetic mechanism driving an oncogene could help determine whether a tumor responds to protein-degrading therapies, potentially providing a new consideration for selecting patients for this emerging class of cancer drugs. The results suggest that tumors in which an oncogene…...

1+ week, 5+ day ago   (463+ words) Researchers have developed a new way to detect small decreases in proteins inside living cells, creating an amplified signal that could make it easier to discover drugs that eliminate disease-causing proteins. The approach, called ratiometric transcriptional activation (RTA), converts the…...

3+ week, 2+ day ago   (397+ words) Researchers at Weill Cornell Medicine have identified a previously unknown link between amino acid metabolism and prostate cancer’s resistance to hormone therapy. Published in Nature Metabolism, the preclinical study found that prostate cancer cells can hijack the metabolism of two…...

1+ mon, 5+ day ago   (520+ words) FLT3 inhibitors have changed the treatment landscape for FLT3-mutant acute myeloid leukemia, but they have not solved the central problem of relapse. Responses to drugs such as gilteritinib can be clinically meaningful, yet resistance frequently emerges, leaving researchers looking for the…...

1+ mon, 1+ week ago   (437+ words) Advice on how much protein to eat should be tailored according to physical activity and lowering intake could be of benefit to many people, possibly even increasing their lifespans. A review of more than 350 research papers, in Cell Press Blue,…...

1+ mon, 3+ week ago   (422+ words) A decades-long mystery surrounding one of the nervous system’s most important molecular machines has been solved, providing a structural blueprint that could accelerate the development of targeted therapies for several inherited neurodegenerative diseases. Although kinesin-1 was the first member of…...

2+ mon, 6+ day ago   (304+ words) The study, published in Nature, explains how disease-causing mutations alter the human acetylcholine receptor (AChR), the protein responsible for converting nerve signals into muscle contraction. The findings also provide a framework for developing precision medicines tailored to the specific mutation…...

2+ mon, 1+ week ago   (442+ words) Researchers have uncovered the molecular mechanism bacteria use to build a family of natural anticancer compounds, a discovery that could help scientists engineer improved versions of histone deacetylase (HDAC) inhibitors for cancer treatment. The study, published in Nature Communications, identifies…...